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Although glutathione is already produced inside the body, its levels can decrease due to ageing factors, stress, pollution or improper diet

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In a mouse model of inflammation, the decrease of LPS-induced paw edema by DATS was associated with reduced serum concentrations of the pro-inflammatory cytokines, TNF-, IL-6, and monocyte chemotactic protein-1 (MCP-1) (36)

Glutamate is converted to -KG both via GLUD1, generating glutamate-derived nitrogen as ammonia, and via aminotransferases, which transfer nitrogen from glutamate to -KG to produce other NEAAs